USP4 Antibody

• Catalog number
  6131-50
• Price
  Please ask
• Size
  50 μg

• Antibody Target
  USP4
• Target Alternative Name
  Deubiquitinating enzyme 4, Ubiquitin carboxyl-terminal hydrolase 4, Ubiquitin-specific-processing, protease 4, Ubiquitin thioesterase 4, Ubiquitous nuclear protein homolog, UNP, Unph, UNPH, Ubiquitin-specific-processing protease 4.
• Antibody Type
  Polyclonal
• Species Reactivities
  Human
• Immunogen Sequence
  Recombinant full length protein
• Accession
  Q13107
• Gene Id
  7375
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  50 µg of antibody in PBS containing 10% glycerol
• Purification
  Purified from egg yolk
• Application
  Western blot
• Application And Usages
  Western blot: Robust detection of 100 ng of recombinant protein was possible when antibody was used at a final concentration of 5 μg/mL
• Description
  Ubiquitinating enzymes (UBEs) catalyze protein ubiquitination, a reversible process countered by deubiquitinating enzyme (DUB) action. Five DUB subfamilies are recognized, including the USP, UCH, OTU, MJD, and JAMM enzymes. USP4 was originally identified during a survey of murine genes near the Mpv20 retroviral insertion site and initially referred to as Ubiquitous Nuclear Protein (UNP). Analysis of the mouse cDNA originally identified Usp4/Unp as a proto-oncogene related to the human tre-2/tre-17/USP6 proto-oncogene. Usp4/Unp was subsequently observed to contain the conserved Cys and His boxes of the UBP family as well as DUB activity. In a study of primary lung tumor tissue, it was observed that the human homolog of Usp4, USP4/UNPH, had elevated gene expression levels in small cell tumors and adenocarcinomas of the lung, suggesting a causative role for USP4 in neoplasia. Another recent study demonstrated overexpression of USP4 in several types of human cancer and that USP4 positively contributes to cell transformation by negatively regulating p53 levels. Both murine and human USP4 have been shown to interact with the Rb family of tumor suppressor proteins, providing additional mechanistic evidence of a role for USP4 in cellular transformation.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  USP4  
• Gene symbol
  USP4
• Short name
  USP4 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Chicken IgG
• Alternative name
  ubiquitin specific peptidase 4 (proto-oncogene) (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  ubiquitin specific peptidase 4 (proto-oncogene), UNP and Unph, USP4 and IDBG-34595 and ENSG00000114316 and 102724426,7375, metal ion binding, nuclei, Usp4 and IDBG-199676 and ENSMUSG00000032612 and 22258, USP4 and IDBG-646000 and ENSBTAG00000011899 and 508042

Gene info

• Identity
  HGNC:12627
• Gene
  USP4
• Long gene name
  ubiquitin specific peptidase 4
• Synonyms gene
  • UNP
• Synonyms gene name
  • ubiquitin specific peptidase 4 (proto-oncogene)
• Synonyms
  • Unph
• GenBank acession
  • U20657
• Locus
  3p21.31
• Discovery year
  1998-05-29
• Entrez gene record
  7375
• Pubmed identfication
  • 12838346
  • 9464533
• RefSeq identity
  • NM_199443
• Classification
  • Ubiquitin specific peptidases
• VEGA ID
  OTTHUMG00000156825

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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