TCS-359

Alternative_name

2-(3,4-dimethoxybenzamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
Description

TCS-359 is a potent, ATP-competitive inhibitor of FLT3 receptor tyrosine kinase (IC₅₀ = 42 nM) that displays selectivity over a range of other kinases. It blocks the proliferation of myelomonocytic leukemia MV4-11 cells. TCS-359 synergistically increases the cytotoxicity of an AF4-mimetic peptide against MV4-11 cells.
CAS Number

301305-73-7
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₈H₂₀N₂O₄S
Molecular Weight

360.43
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>10 mg/ml)
Handling

Protect from air and light
Tag Line

A potent, ATP-competitive FLT3 receptor tyrosine kinase inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

1048845
PubChem CID Link
SMILES

COC1=C(C=C(C=C1)C(=O)NC2=C(C3=C(S2)CCCC3)C(=O)N)OC
InChi

InChI=1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)
InChi Key

FSPQCTGGIANIJZ-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes