Leucettine L41

Alternative_name

(5Z)-5-(1,3-Benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4one
Description

A potent inhibitor of DYRKs and CLKs. Interacts also with GSK-3α/β, CK2 and PIM1. Interacts with the complex IKfyve/Vac14/Fig4. Modulates alternative splicing of pre-mRNA in various cellular systems. Neuroprotective against APP-induced cell death. Useful to study and modulate pre-RNA splicing. Potential compound for Alzheimer's disease and diseases involving abnormal pre-mRNA splicing. Potential compound to study Down syndrome (inhibition of DYRK1A). Neuroprotective against glutamate-induced cell death.
CAS Number

1112978-84-3
Structure Available

Y
Salt Form

No
Molecular Formula

C₁₇H₁₃N₃O₃
Molecular Weight

307.3
Cell Permeable

Yes
Purity

>98% by NMR
Solubilities

DMSO or EtOH
Handling

Protect from air and light
Tag Line

A potent inhibitor of DYRKs and CLKs
Storage Condition

-20 ̊C
Shipping Condition

Gel pack
Shelf Life

36 months
SMILES

O=C1NC(NC2=CC=CC=C2)=N/C1=C\C3=CC=C(OCO4)C4=C3
InChi

InChI=1S/C17H13N3O3/c21-16-13(8-11-6-7-14-15(9-11)23-10-22-14)19-17(20-16)18-12-4-2-1-3-5-12/h1-9H,10H2,(H2,18,19,20,21)/b13-8-
InChi Key

PGPHHJBZEGSUNE-JYRVWZFOSA-N
Data Sheet Link
MSDS Available

Yes