Leucettine L41
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Catalog number2617-1
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PricePlease ask
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Size1 mg
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Alternative_name(5Z)-5-(1,3-Benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4one
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DescriptionA potent inhibitor of DYRKs and CLKs. Interacts also with GSK-3α/β, CK2 and PIM1. Interacts with the complex IKfyve/Vac14/Fig4. Modulates alternative splicing of pre-mRNA in various cellular systems. Neuroprotective against APP-induced cell death. Useful to study and modulate pre-RNA splicing. Potential compound for Alzheimer's disease and diseases involving abnormal pre-mRNA splicing. Potential compound to study Down syndrome (inhibition of DYRK1A). Neuroprotective against glutamate-induced cell death.
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CAS Number1112978-84-3
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Structure AvailableY
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Salt FormNo
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Molecular FormulaC₁₇H₁₃N₃O₃
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Molecular Weight307.3
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Cell PermeableYes
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Purity>98% by NMR
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SolubilitiesDMSO or EtOH
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HandlingProtect from air and light
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Tag LineA potent inhibitor of DYRKs and CLKs
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Storage Condition-20 ̊C
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Shipping ConditionGel pack
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Shelf Life36 months
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SMILESO=C1NC(NC2=CC=CC=C2)=N/C1=C\C3=CC=C(OCO4)C4=C3
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InChiInChI=1S/C17H13N3O3/c21-16-13(8-11-6-7-14-15(9-11)23-10-22-14)19-17(20-16)18-12-4-2-1-3-5-12/h1-9H,10H2,(H2,18,19,20,21)/b13-8-
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InChi KeyPGPHHJBZEGSUNE-JYRVWZFOSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolRPL41
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Short nameLeucettine L41
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Alternative nameLeucettine L41
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Gene info
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Identity
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Gene
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Long gene nameribosomal protein L41
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Synonyms
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GenBank acession
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Locus
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Discovery year1993-01-19
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Entrez gene record
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Pubmed identfication
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Classification
- L ribosomal proteins
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VEGA ID