BAR-501

• Catalog number
  B1591-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  (3R,5S,6S,7S,8S,9S,10S,13R,14S,17R)-6-ethyl-17-((R)-5-hydroxypentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol
• Description
  BAR-501 is a selective GPBAR1 agonist devoid of any FXR agonistic activity. It effectively transactivates GPBAR1 in HEK293 cells overexpressing a CRE along with GPBAR1, with an EC₅₀ of 1 μM. Exposure of GLUTAg cells to BAR501 (10 μM) increases the expression of GLP-1 mRNA by 2.5 folds.
• CAS Number
  1632118-69-4
• Structure Available
  Yes
• Molecular Formula
  C₂₆H₄₆O₃
• Molecular Weight
  406.65
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  selective GPBAR1 agonist devoid of any FXR agonistic activity
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  101886302
• PubChem CID Link
• SMILES
  CC1C2CC(CCC2(C3CCC4(C(C3C1O)CCC4C(C)CCCO)C)C)O
• InChi
  InChI=1S/C26H46O3/c1-5-18-22-15-17(28)10-12-26(22,4)21-11-13-25(3)19(16(2)7-6-14-27)8-9-20(25)23(21)24(18)29/h16-24,27-29H,5-15H2,1-4H3/t16-,17-,18+,19-,20+,21+,22+,23+,24+,25-,26-/m1/s1
• InChi Key
  DQBAHTQWQZRMFH-CRPAWOMZSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  BAR-501  
• Gene symbol
  BFAR, MIR501, ADRB2, AP1AR, GPBAR1
• Short name
  BAR-501
• Alternative name
  BAR-501

Gene info

• Identity
  HGNC:17613
• Gene
  BFAR
• Long gene name
  bifunctional apoptosis regulator
• Synonyms
  • BAR
  • RNF47
• GenBank acession
  • AF173003
• Locus
  16p13.12
• Discovery year
  2002-05-29
• Entrez gene record
  51283
• Pubmed identfication
  • 10716992
• RefSeq identity
  • NM_016561
• Classification
  • Sterile alpha motif domain containing
  • Ring finger proteins
• VEGA ID
  OTTHUMG00000129848

Gene info

• Identity
  HGNC:32135
• Gene
  MIR501
• Long gene name
  microRNA 501
• Synonyms gene
  • MIRN501
• Synonyms
  • hsa-mir-501
• Locus
  Xp11.23
• Discovery year
  2005-07-15
• Entrez gene record
  574503
• RefSeq identity
  • NR_030225
• Classification
  • MicroRNA MIR500 family

Gene info

• Identity
  HGNC:286
• Gene
  ADRB2
• Long gene name
  adrenoceptor beta 2
• Synonyms gene
  • ADRB2R
• Synonyms gene name
  • adrenergic, beta-2-, receptor, surface
  • adrenoceptor beta 2, surface
• Synonyms
  • ADRBR
  • BAR
  • B2AR
• GenBank acession
  • AF022953
• Locus
  5q32
• Discovery year
  1990-09-10
• Entrez gene record
  154
• RefSeq identity
  • NM_000024
• Classification
  • Adrenoceptors
• VEGA ID
  OTTHUMG00000129933

Gene info

• Identity
  HGNC:28808
• Gene
  AP1AR
• Long gene name
  adaptor related protein complex 1 associated regulatory protein
• Synonyms gene
  • C4orf16
• Synonyms gene name
  • chromosome 4 open reading frame 16
  • adaptor-related protein complex 1 associated regulatory protein
• Synonyms
  • PRO0971
  • 2C18
  • gamma-BAR
• Synonyms name
  • gamma1-adaptin brefeldin A resistance
• GenBank acession
  • AL136628
• Locus
  4q25
• Discovery year
  2004-09-15
• Entrez gene record
  55435
• Pubmed identfication
  • 15775984
• RefSeq identity
  • NM_018569
• VEGA ID
  OTTHUMG00000132849

Gene info

• Identity
  HGNC:19680
• Gene
  GPBAR1
• Long gene name
  G protein-coupled bile acid receptor 1
• Synonyms
  • BG37
  • GPCR
  • TGR5
  • M-BAR
  • GPCR19
  • GPR131
  • MGC40597
• GenBank acession
  • AB086170
• Locus
  2q35
• Discovery year
  2003-01-24
• Entrez gene record
  151306
• Pubmed identfication
  • 12419312
• RefSeq identity
  • NM_001077191
• Classification
  • G protein-coupled bile acid receptor
• VEGA ID
  OTTHUMG00000155203

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