Active BCL2L1 Protein, human recombinant
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Catalog number
7885-10
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Price
Please ask
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Size
10 ug
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Synonyms
Bcl-2-like protein 1, Bcl2-L-1, Bcl-X, BCL2L, BCLX
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Alternative_names
Bcl-2-like protein 1, Bcl2-L-1, Bcl-X, BCL2L, BCLX
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Description
A Potent inhibitor of cell death that inhibits the activation of caspases.
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Recombinant
Yes
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Source
E. coli
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Purity by SDS PAGE
>92%
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Assay
SDS-PAGE
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Molecular Weight
24.6 kDa
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Storage Temp
+4°C
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Shipping
Gel pack
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Shelf Life
12 months
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Appearance
Dry powder
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Physical form description
Lyophilized powder
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Reconstitution Instructions
Reconstitute in sterile deionized water to a stock solution of 200 µg/mL. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% (W/V) HSA or BSA) is recommended for further dilution and long term storage.
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Background Information
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F1F0 activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. Isoform Bcl-X(S) promotes apoptosis.
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Amino acid sequence
Met 1 - Arg 212
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Handling
Centrifuge the vial prior to opening.
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Usage
For Research Use Only! Not to be used in humans
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
BCL2L1-AS1, BCL2L1
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Short name
Active BCL2L1 Protein, recombinant
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Species
Human, Humans
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Alternative name
functionnal B-cellular CLL/lymphoma 2-like 1 Protein, H. sapiens Rec.
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Alternative technique
rec
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Alternative to gene target
BCL2-like 1, Bcl-X and bcl-xL and BCL-XL/S and bcl-xS and BCL2L and BCLX and BCLXL and BCLXS and PPP1R52, BCL2L1 and IDBG-63673 and ENSG00000171552 and 598, BH3 domain binding, nuclei, Bcl2l1 and IDBG-209867 and ENSMUSG00000007659 and 12048, BCL2L1 and IDBG-641541 and ENSBTAG00000006526 and 282152
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Gene info
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Identity
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Gene
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Long gene name
BCL2L1 antisense RNA 1
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Locus
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Discovery year
2019-07-24
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Entrez gene record
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Classification
Gene info
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Identity
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Gene
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Long gene name
BCL2 like 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
1997-10-30
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- BCL2 family
- Protein phosphatase 1 regulatory subunits
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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