Amuvatinib

• Catalog number
  9458-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  N-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-(benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide; MP-470; HPK56
• Description
  Amuvatinib (MP-470) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC₅₀ values of 10 nM, 40 nM and 81 nM, respectively. It also disrupts DNA repair likely through suppression of Homologous Recombination protein Rad51.
• CAS Number
  850879-09-3
• Structure Available
  Yes
• Molecular Formula
  C₂₃H₂₁N₅O₃S
• Molecular Weight
  447.51
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>30 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A multi-targeted tyrosine kinase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel pack
• Shelf Life
  36 months
• PubChem CID
  11282283
• PubChem CID Link
• SMILES
  C1CN(CCN1C2=NC=NC3=C2OC4=CC=CC=C43)C(=S)NCC5=CC6=C(C=C5)OCO6
• InChi
  InChI=1S/C23H21N5O3S/c32-23(24-12-15-5-6-18-19(11-15)30-14-29-18)28-9-7-27(8-10-28)22-21-20(25-13-26-22)16-3-1-2-4-17(16)31-21/h1-6,11,13H,7-10,12,14H2,(H,24,32)
• InChi Key
  FOFDIMHVKGYHRU-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Amuvatinib  
• Short name
  Amuvatinib
• Alternative name
  Amuvatinib

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