AHU-377

Alternative_name

4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate; Sacubitril
Description

AHU-377 is a prodrug that is activated in vivo by esterases to form an active compound LBQ657 which acts as a potent and selective neprilysin inhibitor. Neprilysin is a protease responsible for the degradation of atrial and brain natriuretic peptides. Inhibition of neprilysin prevents the degradation of natriuretic peptides and activates cGMP signaling pathways that regulate volume and blood pressure.
CAS Number

149709-62-6
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₄H₂₉NO₅
Molecular Weight

411.49
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>5 mg/ml)
Handling

Protect from air and light
Tag Line

A potent and selective neprilysin inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

9811834
PubChem CID Link
SMILES

CCOC(=O)C(C)CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O
InChi

InChI=1S/C24H29NO5/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28)/t17-,21+/m1/s1
InChi Key

PYNXFZCZUAOOQC-UTKZUKDTSA-N
Data Sheet Link
MSDS Available

Yes