BRD2 Antibody

• Catalog number
  6281-100
• Price
  Please ask
• Size
  100 μg

• Antibody Target
  BRD2
• Target Alternative Name
  RING3, RNF3; Bromodomain containing 4
• Antibody Type
  Polyclonal
• Species Reactivities
  Human, mouse, rat
• Immunogen Sequence
  Synthetic peptide at N-terminal
• Accession
  Q6 mgA9
• Gene Id
  294276
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  0.5 mg/ml
• Formulation
  100 µg (0.5 mg/ml) of antibody in PBS, 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol, pH 7.2
• Purification
  Affinity purified antibody
• Application
  Western blot
• Positive Control
  Western blot: 3T3 cell lysate
• Application And Usages
  Western blot: 1:200
• Description
  The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. The BET family of proteins, defined by tandem Bromodomains and an Extra Terminal domain, include BRD2, BRD3, BRD4, and BRDT. The BET proteins play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interactions. The isolated individual or tandem bromodomains of BRD2 and BRD4 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters. Small molecule inhibitors of these interactions hold promise as useful therapeutics for human disease.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Flow Cytometry Verified
  Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  BRD2  
• Gene symbol
  BRD2
• Short name
  BRD2 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  BRD2 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:1103
• Gene
  BRD2
• Long gene name
  bromodomain containing 2
• Synonyms gene
  • BRD2-IT1
• Synonyms gene name
  • bromodomain-containing 2
  • BRD2 intronic transcript 1
• Synonyms
  • KIAA9001
  • RING3
  • D6S113E
  • NAT
  • FSRG1
• GenBank acession
  • X96670
• Locus
  6p21.32
• Discovery year
  2000-07-25
• Entrez gene record
  6046
• Pubmed identfication
  • 1352711
  • 8781126
• Classification
  • Bromodomain and extra-terminal domain family
  • Bromodomain containing
• VEGA ID
  OTTHUMG00000031241

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

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