LOX-1 Antibody
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Catalog number3659R-100
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PricePlease ask
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Size100 µg
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Antibody TargetLOX-1
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Target Alternative NameLOK, Lymphocyte Oriented Kinase, STK10, STK-10, Serine/Threonine Kinase 10
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Antibody TypePolyclonal
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Species ReactivitiesHuman, mouse, rat
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Immunogen SequenceSynthetic peptide near the N-terminus of human Lox-1
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AccessionP78380
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Gene Id4973
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AppearanceColorless liquid
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FormLiquid
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Concentration0.5 mg/ml
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Formulation100 µg (0.5 mg/ml) affinity purified rabbit anti-LOX-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
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PurificationAffinity purified
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ApplicationWestern blot, Immunohistochemistry
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Application And UsagesWestern blotting (0.5-4 µg/ml), detecting the pro- (~50 kDa) and the mature (~30 kDa) forms of Lox-1 in samples from human, mouse and rat origins. Other applications have not been determined.
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DescriptionLectin-like oxidized low-density-lipoprotein receptor-1 (LOX-1), also known as oxidized low-density-lipoprotein receptor-1 (OLR-1), belongs to the C-type lectin family. LOX-1 binds and supports the internalization of multiple structurally unrelated macromolecules including oxidized LDL, advanced glycation end products (AGE), activated platelets, bacteria, apoptotic or aged cells, and heat shock proteins. Human LOX-1 gene encodes a 273 amino acid residues (aa) protein with a short N-terminal intracellular domain, a transmembrane domain, an extracellular stalk/neck region followed a C-type lectin-like domain (CTLD). The expression of LOX-1 is induced by proinflammatory or proatherogenic stimuli, as well as by oxidized LDL itself and hemodynamic or oxidative stress. LOX-1-dependent oxidized LDL uptake also induces apoptosis by inducing the expression of the pro-apoptotic Bax and downregulation of the anti-apoptotic Bcl-2.
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Storage Condition-20 °C
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Shipping Conditiongel pack
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Shelf Life12 months
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UsageFor Research Use Only! Not to be used in humans.
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HandlingThe antibody solution should be gently mixed before use.
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Western Blot VerifiedVerified
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Immunocytochemistry VerifiedNot Verified
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Immunofluorescence VerifiedNot Verified
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Immunoprecipitation VerifiedNot Verified
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FACS VerifiedNot Verified
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ELISA VerifiedNot Verified
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ChIP VerifiedNot Verified
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Flow Cytometry VerifiedNot Verified
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PropertiesIf you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolLOX, ALOX15, OLR1, ALOX5, ALOX12B, ALOX12, ALOX15B, ALOXE3, IGHVII-1-1, MIR1-1
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Short nameLOX-1 Antibody
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeRabbit IgG
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Alternative nameLOX-1 (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namelysyl oxidase
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Synonyms name
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namearachidonate 15-lipoxygenase
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Synonyms
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GenBank acession
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Locus
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Discovery year1992-11-20
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Entrez gene record
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Pubmed identfication
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Classification
- Arachidonate lipoxygenases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameoxidized low density lipoprotein receptor 1
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Synonyms gene name
- oxidised low density lipoprotein (lectin-like) receptor 1
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-01-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C-type lectin domain containing
- Scavenger receptors
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namearachidonate 5-lipoxygenase
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Synonyms
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GenBank acession
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Locus
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Discovery year1992-07-10
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Entrez gene record
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Pubmed identfication
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Classification
- Arachidonate lipoxygenases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namearachidonate 12-lipoxygenase, 12R type
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-07-22
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Entrez gene record
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Pubmed identfication
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Classification
- Arachidonate lipoxygenases
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namearachidonate 12-lipoxygenase, 12S type
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Synonyms gene name
- arachidonate 12-lipoxygenase
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1991-08-07
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Entrez gene record
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Pubmed identfication
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Classification
- Arachidonate lipoxygenases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namearachidonate 15-lipoxygenase type B
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Synonyms gene name
- arachidonate 15-lipoxygenase, second type
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-07-22
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Entrez gene record
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Pubmed identfication
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Classification
- Arachidonate lipoxygenases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namearachidonate lipoxygenase 3
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2000-11-29
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Entrez gene record
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Pubmed identfication
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Classification
- Arachidonate lipoxygenases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin heavy variable (II)-1-1 (pseudogene)
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Synonyms gene name
- immunoglobulin heavy variable (II)-1-1
- immunoglobulin heavy variable (II)-1-1 pseudogene
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-04-17
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin heavy locus at 14q32.33
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemicroRNA 1-1
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Synonyms gene
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Synonyms
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Locus
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Discovery year2004-04-23
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR1/206 family
MeSH Data
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Name
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ConceptScope note: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
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Tree numbers
- E05.393.220
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Qualifiersdrug effects, methods, radiation effects
