Necrostatin-1

• Catalog number
  1864-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone; Methylthiohydantoin-DL-tryptophan; Nec-1
• Description
  Inhibits necroptosis, a non-apoptotic cell death pathway. Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. Inhibits RIP1 kinase, the key upstream kinase involved in the activation of necroptosis (EC₅₀ = 180 nM).
• CAS Number
  4311-88-0
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₃H₁₃N₃OS
• Molecular Weight
  259.33
• Cell Permeable
  Yes
• Purity
  ≥98% by TLC
• Solubilities
  DMSO (~25 mg/ml) or EtOH (~ 6 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A necroptosis inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD00056916
• PubChem CID
  2828334
• PubChem CID Link
• SMILES
  CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32
• InChi
  InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
• InChi Key
  TXUWMXQFNYDOEZ-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Necrostatin-1  
• Short name
  Necrostatin-1
• Alternative name
  Necrostatin-1

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