TAS-120

Alternative_name

1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-pyrrolidinyl]-2-propen-1-one
Description

TAS-120 is a novel, potent and highly selective FGFR inhibitor that irreversibly inhibits all four FGFR subtypes at nanomolar concentrations. It blocks the phosphorylation of FGFRs and impedes downstream signaling pathways in cells. TAS-120 prevents the proliferation of human cancer cell lines with FGFR gene abnormalities but does not alter the growth of cell lines with wild-type FGFR.
CAS Number

1448169-71-8
Structure Available

Yes
Molecular Formula

C₂₂H₂₂N₆O₃
Molecular Weight

418.5
Cell Permeable

1
Purity

≥98% by HPLC
Solubilities

>25 mg/ml (DMSO) in 0
Handling

Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Tag Line

A potent and highly selective FGFR inhibitor
Storage Condition

-20ºC
Shipping Condition

Gel Pack
Shelf Life

36 months
PubChem CID

71621331
PubChem CID Link
SMILES

COC1=CC(=CC(=C1)C#CC2=NN(C3=C2C(=NC=N3)N)C4CCN(C4)C(=O)C=C)OC
InChi

InChI=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/m0/s1
InChi Key

KEIPNCCJPRMIAX-HNNXBMFYSA-N
Data Sheet Link
MSDS Available

1

Identity

HGNC:7476
Gene

MT-TAS
Long gene name

mitochondrially encoded termination associated sequence
Synonyms gene
- MTTAS
Synonyms gene name
- termination associated sequence
- mitochondrially encoded termination associate sequence
Locus

mitochondria
Discovery year

1989-10-11
Pubmed identfication
- 9473475
Classification
- Mitochondrially encoded regions

Identity

HGNC:2243
Gene

COPZ1
Long gene name

COPI coat complex subunit zeta 1
Synonyms gene
- COPZ
Synonyms gene name
- coatomer protein complex, subunit zeta
- coatomer protein complex, subunit zeta 1
Synonyms
- CGI-120
GenBank acession
- AF151878
Locus

12q13.13
Discovery year

1999-09-28
Entrez gene record

22818
RefSeq identity
- NM_016057
Classification
- COPI coat complex
- MicroRNA protein coding host genes
VEGA ID

OTTHUMG00000169762