anti- PSTPIP1 antibody

• Catalog number
  FNab06903
• Price
  Please ask
• Size
  2X100μg

• Form
  liquid
• Purification
  Immunogen affinity purified
• Purity
  ≥95% as determined by SDS-PAGE
• Storage
  PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
• Background
  This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response.
• Immunogen
  proline-serine-threonine phosphatase interacting protein 1
• Synonyms
  CD2BP1
• Calculated MW
  48 kDa
• Uniprot ID
  O43586
• Specificity
  Human, Mouse, Rat
• Tested Application
  ELISA, WB, IHC
• Recommended dilution
  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
• Image1
  Immunohistochemistry of paraffin-embedded human brain using FNab06903(PSTPIP1 antibody) at dilution of 1:50
• Image4
  mouse thymus tissue were subjected to SDS PAGE followed by western blot with FNab06903(PSTPIP1 antibody) at dilution of 1:1000
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Properties
  If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PSTPIP1  
• Gene symbol
  PSTPIP1
• Short name
  anti- PSTPIP1 antibody
• Technique
  Antibody, anti, antibody to, antibodies against human proteins, antibodies for
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  antibody to- proline-serine-threonine phosphatase interacting protein 1 (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  proline-serine-threonine phosphatase interacting protein 1, CD2BP1 and CD2BP1L and CD2BP1S and H-PIP and PAPAS and PSTPIP, PSTPIP1 and IDBG-24106 and ENSG00000140368 and 9051, protein phosphatase binding, Plasma membranes, Pstpip1 and IDBG-168522 and ENSMUSG00000032322 and 19200, PSTPIP1 and IDBG-631349 and ENSBTAG00000021144 and 513924

Gene info

• Identity
  HGNC:9580
• Gene
  PSTPIP1
• Long gene name
  proline-serine-threonine phosphatase interacting protein 1
• Synonyms
  • PSTPIP
  • CD2BP1L
  • CD2BP1
  • CD2BP1S
  • H-PIP
  • PAPAS
• Synonyms name
  • CD2 cytoplasmic tail-binding protein
  • CD2 antigen-binding protein 1
  • PEST phosphatase-interacting protein 1
• GenBank acession
  • U94778
• Locus
  15q24.3
• Discovery year
  1999-01-12
• Entrez gene record
  9051
• Pubmed identfication
  • 9857189
• RefSeq identity
  • NM_003978
• Classification
  • F-BAR domain containing
• VEGA ID
  OTTHUMG00000172594
• Locus Specific Databases
  • PAPA syndrome: INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations
  • LRG_172

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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