RG-7112

Alternative_name

((4S,5R)-2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl)(4-(3-(methylsulfonyl)propyl)piperazin-1-yl)methanone; RG7112; RO5045337
Description

RG-7112 is a Nutlin imidazoline compound that acts as a potent MDM2 inhibitor as well as displays antineoplastic activity. RG-7112 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53.
CAS Number

939981-39-2
Structure Available

Yes
Salt Form

No
Molecular Formula

C₃₈H₄₈Cl₂N₄O₄S
Molecular Weight

727.78
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

A potent MDM2 inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

57406853
PubChem CID Link
SMILES

CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C(N2C(=O)N3CCN(CC3)CCCS(=O)(=O)C)(C)C4=CC=C(C=C4)Cl)(C)C5=CC=C(C=C5)Cl
InChi

InChI=1S/C38H48Cl2N4O4S/c1-8-48-33-26-29(36(2,3)4)14-19-32(33)34-41-37(5,27-10-15-30(39)16-11-27)38(6,28-12-17-31(40)18-13-28)44(34)35(45)43-23-21-42(22-24-43)20-9-25-49(7,46)47/h10-19,26H,8-9,20-25H2,1-7H3/t37-,38+/m0/s1
InChi Key

QBGKPEROWUKSBK-QPPIDDCLSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:1323
Gene

C4A
Long gene name

complement C4A (Rodgers blood group)
Synonyms gene name
- complement component 4A
- complement component 4A (Rodgers blood group)
Synonyms
- CPAMD2
- C4S
- CO4
- C4
- C4A3
- C4A2
- C4A4
- C4A6
- C4B
- RG
GenBank acession
- L26261
- M14823
- X77491
- AY224378
Locus

6p21.33
Discovery year

2001-06-22
Entrez gene record

720
RefSeq identity
- NM_007293
Classification
- C3 and PZP like, alpha-2-macroglobulin domain containing
- Blood group antigens
- Complement system activation components
VEGA ID

OTTHUMG00000031186
Locus Specific Databases
- LRG_137