trans-ISRIB

• Catalog number
  B1906-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]; ISRIB
• Description
  trans-ISRIB is an integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation (IC₅₀ = 5 nM). Enhances spatial and fear-associated learning in mice and enhances cognitive function. Mechanism of action involves activation of eiF2β. Suppresses ER stress-induced inflammatory gene expression. Potently attenuates amyloid β-induced neuronal cell death (12.5-25 nM) with no effect on amyloid β production. Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models.
• CAS Number
  1597403-47-8
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₂H₂₄Cl₂N2₂O₄
• Molecular Weight
  451.3
• Cell Permeable
  Yes
• Purity
  ≥98% by TLC
• Solubilities
  DMSO (~ 5 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  An integrated stress response inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  1011240
• PubChem CID Link
• SMILES
  C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl
• InChi
  InChI=1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2,(H,25,27)(H,26,28)
• InChi Key
  HJGMCDHQPXTGAV-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  trans-ISRIB  
• Short name
  trans-ISRIB
• Alternative name
  trans-ISRIB

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