anti-PUMA Antibody [10C5G1]

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• Catalog number
  PM-4527
• Price:

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• Size
  0.02 mg, 0.1 mg

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• Gene info
  PUMA Monoclonal Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAa; and PUMAβ. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
• Gene names
  PUMA Antibody [10C5G1] : JFY1, PUMA, JFY-1
• Antibodie s label
  unlabelled serum
• Purity
  PUMA Monoclonal Antibody is immunoaffinity chromotography purified IgG.
• Ab raised in
  Mouse
• Type
  Monoclonal
• Monoclonal
  10C5G1
• Immunoglobulin
  IgG1
• Antigen
  Recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha.
• Immuno application
  ELISA, Western Blot
• Antibody advice
  PUMA antibody can be used for detection of PUMA by Western blot at 2.5 to 5 ug/mL.
• Suspention pH azide
  PUMA Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  PUMA monoclonal antibody can be stored at -20 grades C, stable for one year.
• Works with
  Human, Rat
• Omim nr
  56748610
• Ncbi nr
  Q9BXH1
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  27113
• GENE symbol
  BBC3
• Antigene name
  BCL2 binding component 3
• Source
  Homo sapiens
• Protein nr
  Q9BXH1
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

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• Gene target
  PUMA   [10C5G1]  
• Gene symbol
  BBC3, HCAR2
• Short name
  anti-PUMA Antibody [10C5G1]
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toPUMA (antibody to-) [10C5G1]
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:17868
• Gene
  BBC3
• Long gene name
  BCL2 binding component 3
• Synonyms
  • JFY1
  • PUMA
• Synonyms name
  • p53-upregulated modulator of apoptosis
• GenBank acession
  • AF332558
• Locus
  19q13.32
• Discovery year
  2002-07-22
• Entrez gene record
  27113
• Pubmed identfication
  • 11463392
  • 11572983
• RefSeq identity
  • NM_014417
• Classification
  • BCL2 homology region 3 (BH3) only
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000183489

Gene info

• Identity
  HGNC:24827
• Gene
  HCAR2
• Long gene name
  hydroxycarboxylic acid receptor 2
• Synonyms gene
  • GPR109A
• Synonyms gene name
  • G protein-coupled receptor 109A
• Synonyms
  • HCA2
  • HM74A
  • PUMAG
  • Puma-g
  • NIACR1
• Synonyms name
  • niacin receptor 1
• GenBank acession
  • AY148884
• Locus
  12q24.31
• Discovery year
  2004-04-22
• Entrez gene record
  338442
• Pubmed identfication
  • 21167710
  • 12522134
  • 12646212
  • 19141678
  • 18983141
  • 21454438
• RefSeq identity
  • NM_177551
• Classification
  • Hydroxycarboxylic acid receptors
• VEGA ID
  OTTHUMG00000162722

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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