CD40Ligand/TRAP, murine recombinant

• Catalog number
  4015-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  CD40-L, Tumor necrosis factor ligand superfamily member 5, TNF-related activation protein, TRAP, T cell antigen Gp39, CD154 antigen, sCD40, IGM, IMD3, HIGM1, T-BAM, TNFSF5, hCD40L.
• Alternative_names
  CD40-L, Tumor necrosis factor ligand superfamily member 5, TNF-related activation protein, TRAP, T cell antigen Gp39, CD154 antigen, sCD40, IGM, IMD3, HIGM1, T-BAM, TNFSF5, hCD40L.
• Description
  A protein primarily expressed on activated T cells and involved in immune functions
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥98%
• Assay
  SDS-PAGE
• Purity
  ≥98%
• Biological activity
  Determined by its ability to induce TNF-α and MIP-1α production by murine splenocytes. The expected ED₅₀ for this effect is
• Molecular Weight
  16.4 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized protein
• Physical form description
  Sterile filtered and then lyophilized from 10 mM Sodium Phosphate, pH 7.5 + 0.1 M Arginine.
• Reconstitution Instructions
  Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers or stored at 4°C for 1 week or –20°C for future use.
• Background Information
  CD40 Ligand (CD40L/TRAP) is a type II transmembrane glycoprotein belonging to the TNF superfamily of ligands. Natually, CD40L is a membrane-bound protein, but proteolytically cleaved 15-18 kDa soluble forms of CD40L are also fully active. CD40L plays an important role in the proliferation and differentiation of B-cells, and is critical for immunoglobulin (Ig) class switching. Recombinant murine CD40 Ligand is a soluble 18 kDa protein containing 149 amino acid residues comprising the receptor binding TNF-like domain of CDE40L.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CD40Ligand/TRAP   murine  
• Gene symbol
  ACP5, TGFBRAP1, CD40LG, SCYL1
• Short name
  CD40Ligand/TRAP, murine recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  CD40Ligand/TRAP, murine Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:124
• Gene
  ACP5
• Long gene name
  acid phosphatase 5, tartrate resistant
• Synonyms
  • TRAP
  • HPAP
• Synonyms name
  • tartrate-resistant acid phosphatase
  • human purple acid phosphatase
• GenBank acession
  • X14618
• Locus
  19p13.2
• Discovery year
  1989-02-23
• Entrez gene record
  54
• Pubmed identfication
  • 8449511
  • 2338077
• Classification
  • Acid phosphatases
• VEGA ID
  OTTHUMG00000182036
• Locus Specific Databases
  • LRG_1218

Gene info

• Identity
  HGNC:16836
• Gene
  TGFBRAP1
• Long gene name
  transforming growth factor beta receptor associated protein 1
• Synonyms gene name
  • transforming growth factor, beta receptor associated protein 1
• Synonyms
  • TRAP-1
  • TRAP1
  • VPS3
• Synonyms name
  • VPS3 CORVET complex subunit
• GenBank acession
  • AF022795
• Locus
  2q12.1-q12.2
• Discovery year
  2003-02-11
• Entrez gene record
  9392
• Pubmed identfication
  • 9545258
  • 11278302
  • 26463206
• RefSeq identity
  • NM_004257
• Classification
  • CORVET complex
• VEGA ID
  OTTHUMG00000130809

Gene info

• Identity
  HGNC:11935
• Gene
  CD40LG
• Long gene name
  CD40 ligand
• Synonyms gene
  • HIGM1
  • IMD3
  • TNFSF5
• Synonyms gene name
  • tumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome)
• Synonyms
  • CD40L
  • TRAP
  • gp39
  • hCD40L
  • CD154
• Synonyms name
  • CD40 antigen ligand
  • tumor necrosis factor (ligand) superfamily member 5
  • T-B cell-activating molecule
  • TNF-related activation protein
  • hyper-IgM syndrome
• GenBank acession
  • X67878
• Locus
  Xq26.3
• Discovery year
  1989-06-30
• Entrez gene record
  959
• Pubmed identfication
  • 1427881
  • 7678782
• RefSeq identity
  • NM_000074
• Classification
  • CD molecules
  • Tumor necrosis factor superfamily
• VEGA ID
  OTTHUMG00000022512
• Locus Specific Databases
  • CD40Lbase: Mutation registry for X-linked Hyper-IgM syndrome
  • Global Variome shared LOVD
  • LRG_141

Gene info

• Identity
  HGNC:14372
• Gene
  SCYL1
• Long gene name
  SCY1 like pseudokinase 1
• Synonyms gene
  • NTKL
• Synonyms gene name
  • N-terminal kinase-like
  • SCY1-like 1 (S. cerevisiae)
  • SCY1-like, kinase-like 1
• Synonyms
  • HT019
  • P105
  • GKLP
  • NKTL
  • TAPK
  • TRAP
  • TEIF
  • MGC78454
• Synonyms name
  • teratoma-associated tyrosine kinase
  • telomerase transcriptional elements-interacting factor
  • telomerase regulation-associated protein
• GenBank acession
  • AF225424
• Locus
  11q13.1
• Discovery year
  2001-01-16
• Entrez gene record
  57410
• Pubmed identfication
  • 11118629
• RefSeq identity
  • NM_020680
• Classification
  • Armadillo like helical domain containing
  • SCY1 like pseudokinases
• VEGA ID
  OTTHUMG00000166325

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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