- Catalog numberGENTObs-11307R-A594
- Product nameAnti-Prostaglandin I2 Receptor, ALEXA Fluor 594
- Size100 microliters
- PriceAsk For Price
- Short nameAnti-Prostaglandin I2 Receptor
- TypeConjugated Primary Antibody
- Conjugated withALEXA FLUOR® 594
- Host organismRabbit (Oryctolagus cuniculus)
- Target Protein PeptideProstaglandin I2 Receptor
- SpecificityThis antibody reacts specifically with Prostaglandin I2 Receptor
- ModificationNo modification has been applied to this antibody
- Modification siteNone
- ClonalityPolyclonal Antibody
- ClonePolyclonal Antibodies
- IsotypeImmunoglobulin G (IgG)
- Concentration1ug per 1ul
- Subcellular locationsExtracellular
- Antigen SourceKLH conjugated synthetic peptide derived from human Prostaglandin I2 Receptor
- Gene IDN/A
- Swiss ProtN/A
- ApplicationsIF(IHC-P)
- Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
- Cross reactive speciesHuman (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
- Cross Reactive Species detailsNo significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
- Background informationCyclooxygenases metabolize arachidonate to five primary prostanoids: PGE2, PGF2?, PGI2, TXA2 and PGD2. These lipid mediators interact with specific members of G protein-coupled prostanoid receptors, designated EP, FP, IP, TP and DP, respectively. The IP Receptor binds prostacyclin, PGI2, the main pro-stanoid synthesized by vascular tissues.Upon binding to the IP Receptor, prostacyclin activates adenylate cyclase primarily through the Gas protein. The gene encoding the human IP Receptor is located on chromosome 19. It is expressed as a glycosylated and phosphorylated protein, which is abundantly expressed in vascular tissues such as aorta, lung, atrium and ventricle, as well as in kidney, thymus, spleen and neurons.
- Purification methodPurified by Protein A.
- StorageWater buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Excitation emission590nm/617nm
- SynonymsIP; PGI receptor; PGI2 receptor; PI2R_HUMAN; PRIPR; Prostacyclin receptor; Prostaglandin I2 receptor; Prostanoid IP receptor; PTGIR.
- Also known asProstaglandin I2 Receptor Antibody
- Other nameAnti-Prostaglandin I2 Receptor
- AdvisoryAvoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
- Gene targetProstaglandin I2 Receptor
- Identity:HGNC:9602
- Gene:PTGIR
- Long gene name:prostaglandin I2 receptor
- Synonyms gene name:prostaglandin I2 (prostacyclin) receptor (IP)
- Synonyms:IP
- Discovery year:1994-07-29
- Entrez gene record:5739
- Pubmed identification:7759114
- Classification:Prostaglandin receptors
- VEGA ID:OTTHUMG00000183429
- Gene symbolPTGIR
- isotype filter
- Immunoglobulin G IgG
- LabelALEXA FLUOR 594
- label filter
- ALEXA FLUOR 594
- technique filter
- anti-
- anti
- Techniqueanti-, anti, antibody to, antibodies
- Alternative techniqueantibodies