M-CSF Recombinant Protein

  • Catalog number
    40-288
  • Supplier
  • Price
    711.3 USD
  • Size
    0.002 mg, 0.01 mg
  • About recombinant protein
    M-CSF is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant human M-CSF is a 36.8 kDa homodimeric protein containing two 159 amino acid polypeptide subunits.
  • Other name of the recombinant
    MCSF, CSF-1, Macrophage colony-stimulating factor 1, Lanimostim
  • Recombinant in
    E. coli
  • SEQUENCE
    MEEVSEYCSH MIGSGHLQSL QRLIDSQMET SCQITFEFVD QEQLKDPVCY LKKAFLLVQD IMEDTMRFRD NTPNAIAIVQ LQELSLRLKS CFTKDYEEHD KACVRTFYET PLQLLEKVKN VFNETKNLLD KDWNIFSKNC NNSFAECSSQ GHERQSEGS
  • Activity
    The ED50 was determined by the dose - dependent stimulation of the proliferation of murine M - NSF - 60 cells ≤ 5 ng/mL, corresponding to a specific activity of ≥ 2 x 105 units/mg.
  • Keep at
    The lyophilized M-CSF recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted M-CSF is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing M-CSF recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
  • Rec PROTEIN GI
    27262661
  • Accession nr
    NP_000748.3
  • Pureity
    Greater than 98% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).
  • About
    This product is for research use only.
  • Protein s origin
    Human
  • Vial
    Lyophilized
  • NCBI ID
    1435
  • Gene name
    colony stimulating factor 1 (macrophage)
  • Source
    Homo sapiens
  • Uniprot
    P09603
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
  • Gene symbol
    CSF1
  • Short name
    M-CSF Recombinant Protein
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Alternative name
    M-CSF Rec. Protein
  • Alternative technique
    rec
Gene info
MeSH Data
  • Name
  • Concept
    Scope note:The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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M CSF Recombinant Protein - Gentaur.com
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