IL-33 Recombinant Protein

• Catalog number
  95-106
• Price
  Please ask
• Size
  0.05 mg

• About recombinant protein
  Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1, IL-1Ra and IL-18 (1,2). Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling (1,3) and IL-1R accessory protein (IL-1RAcP) (4). Receptor binding of IL-33 activates NF-B and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine (2). Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties (5).
• Other name of the recombinant
  IL-33 Antibody: DVS27, IL1F11, NF-HEV, NFEHEV, C9orf26, NFHEV, Interleukin-33, Interleukin-1 family member 11, IL-33
• Recombinant in
  E. coli
• His tag on the recombinant protein
  Fusion Partner: C-terminal His-tag
• SEQUENCE
  aa 1 - 270
• Activity
  not available
• Use of recmbinant
  This recombinant protein can be used for WB, ELISA, MS and neutralization assays. For research use only.
• Protein is used in
  E, WB, MS
• Suspention medium
  100mM sodium phosphate, 500mM NaCl, 25 mM imidazole, 10% gycerol
• Keep at
  Store in working aliquots at -70˚C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• Rec PROTEIN GI
  15559209
• Accession nr
  NP_254274
• KDa of reombinant
  30 kDa (Calculated)
• Pureity
  ~95%
• About
  Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
• Vial
  Liquid
• NCBI ID
  90865
• Gene name
  interleukin 33
• Source
  Homo sapiens
• Uniprot
  O95760
• Pictures of recombinant
• Rec pdf
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  IL-33   Protein  
• Gene symbol
  IL33
• Short name
  IL-33 Recombinant Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  Interleukin-33 Rec. Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:16028
• Gene
  IL33
• Long gene name
  interleukin 33
• Synonyms gene
  • C9orf26
• Synonyms gene name
  • chromosome 9 open reading frame 26 (NF-HEV)
• Synonyms
  • DVS27
  • DKFZp586H0523
  • NF-HEV
  • IL1F11
• Synonyms name
  • DVS27-related protein
  • nuclear factor for high endothelial venules
  • interleukin-1 family, member 11
• GenBank acession
  • AB024518
• Locus
  9p24.1
• Discovery year
  2003-12-18
• Entrez gene record
  90865
• Pubmed identfication
  • 10566975
  • 12819012
• RefSeq identity
  • NM_033439
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000019516

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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