KRAS G12D inhibitor 1

• UNSPSC Description:

  KRAS G12D inhibitor 1 (example 243) is a KRAS G12D inhibitor, with an IC50 of 0.8 nM for KRAS G12D-mediated ERK phosphorylation[1]. KRAS G12D inhibitor 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• Target Antigen:

  Ras

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;MAPK/ERK Pathway

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/kras-g12d-inhibitor-1.html

• Smiles:

  OC1=CC(C2=C(F)C3=NC(OC[C@@]45CCCN4C[C@H](F)C5)=NC(N6C[C@H]7N[C@H](CC7)C6)=C3C=N2)=C8C(C#C)=CC=CC8=C1

• Molecular Weight:

  582.64

• References & Citations:

  [1]WANG XIAOLUN (US), et al. KRAS G12D INHIBITORS. WO2021041671.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  2621928-43-4