Dehydrocorydaline (hydroxyl)

CAT: 0804-HY-N0674B-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0674B-01Size:5 mg
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Description
Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline hydroxyl elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline hydroxyl shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.
Product Name Alternative
13-Methylpalmatine (hydroxyl)
UNSPSC
12352005
Target
Autophagy; Bcl-2 Family; Caspase; p38 MAPK; Parasite; PARP
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; MAPK/ERK Pathway
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dehydrocorydaline-hydroxyl.html
Purity
99.52
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=C(C=CC(OC)=C2OC)C2=C[N+]3=C1C4=CC(OC)=C(OC)C=C4CC3.[OH-]
Molecular Formula
C22H25NO5
Molecular Weight
383.44
References & Citations
[1]Xu Z, et al. Dehydrocorydaline inhibits breast cancer cells proliferation by inducing apoptosis in MCF-7 cells. Am J Chin Med. 2012;40 (1) :177-85.|[2]Yoo M, et al. Dehydrocorydaline promotes myogenic differentiation via p38 MAPK activation. Mol Med Rep. 2016 Oct;14 (4) :3029-36.|[3]Nonaka M, et al. Screening of a library of traditional Chinese medicines to identify anti-malarial compounds and extracts. Malar J. 2018 Jun 25;17 (1) :244.|[4]Yin ZY, et al. Antinociceptive effects of dehydrocorydaline in mouse models of inflammatory pain involve the opioid receptor and inflammatory cytokines. Sci Rep. 2016 Jun 7;6:27129.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Citation 01
Int J Biol Macromol. 2024 May;266 (Pt 1) :130939.|Aging (Albany NY) . 2021 May 11;13 (9) :12780-12799.|Aging (Albany NY) . 2021 Oct 7;13 (19) :23133-23148.|Andrology. 2025 Jun 16.|Arthritis Res Ther. 2025 May 31;27 (1) :118.|Biochem Biophys Res Commun. 2018 May 23;499 (4) :743-750. |Biochem Biophys Res Commun. 2018 Sep 5;503 (2) :467-473. |Biochem Pharmacol. 2024 Dec;230 (Pt 1) :116574.|BMC Musculoskelet Disord. 2022 May 30;23 (1) :514.|Bone Joint Res. 2023 Nov 1;12 (11) :677-690.|Comput Math Methods Med. 2021 Aug 2:2021:3337514.|Eur J Histochem. 2025 Jan 21;69 (1) .|Eur J Pharmacol. 2021 Jun 5:900:174069.|FASEB J. 2025 Aug 31;39 (16) :e70945.|Infect Genet Evol. 2022 Jan:97:105158.|J Agric Food Chem. 2023 Oct 25;71 (42) :15538-15552.|J Cell Physiol. 2019 Dec;234 (12) :22463-22476.|J Clin Neurosci. 2020 Aug;78:365-370.|J Mol Histol. 2021 Jun;52 (3) :521-537.|J Nanobiotechnology. 2025 Jul 22;23 (1) :535.|J Nutr. 2020 Jul 1;150 (7) :1731-1737.|Mol Carcinog. 2024 Nov;63 (11) :2190-2204.|Biochem Pharmacol. 2025 May:235:116820.|Bioengineered. 2022 May;13 (5) :12847-12862.|Ecotoxicol Environ Saf. 2025 Jun 4:300:118460.|Exp Eye Res. 2023 Feb:227:109365.|Front Biosci (Landmark Ed) . 2025 Apr 25;30 (4) :25221.|Front Pharmacol. 2021 May 31:12:653272.|Genomics. 2025 Jun 1:111067.|Int Immunopharmacol. 2024 Jul 23:139:112720.|J Cardiothorac Surg. 2024 Dec 20;19 (1) :665.|J Clin Invest. 2024 Jun 18:e178303.|J Ethnopharmacol. 2024 Aug 31:118738.|J Food Sci. 2025 Apr;90 (4) :e70217.|J Inflamm Res. 2021 Sep 16;14:4669-4686.|New Phytol. 2024 May 13.|Phytomedicine. 2021 Nov:92:153740.|Respir Res. 2025 Apr 12;26 (1) :136.|Tissue Cell. 2023 Dec:85:102218.

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