Recombinant Human Collagen alpha-1(I)chain/COL1A1 protein (GST tag)

Recombinant Human Collagen alpha-1(I)chain/COL1A1 protein (GST tag)

• Background: This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
• Abbreviation: Collagen alpha-1 chain;COL1A1
• Synonyms: Alpha-1 type I collagen, COL1A1, Collagen alpha-1(I) chain
• CAS Number: 9000-83-3
• UniProt: P02452
• Accession Number: P02452
• Host: E. coli
• Origin Species: Human
• Tag: N-GST
• Sequence: Glu 1021-Gly 1109
• Field of Research: Signal Transduction;Cell biology
• Purity: > 95% as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
• Molecular Weight: 35 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.