ML 145

ML 145

• CAS Number: 1164500-72-4
• UNSPSC Description: ML 145 is a selective and competitive human GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM. ML 145 has over 1000-fold more selective for GPR35 compared to GPR55 (IC50/EC50=21.7 μM)[1]. ML 145 has no significant activity for GPR35 at either rodent ortholog[2].
• Target Antigen: CXCR; GPR35
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Immunology/Inflammation
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Inflammation/Immunology; Endocrinology
• Assay Protocol: https://www.medchemexpress.com/ml-145.html
• Purity: 97.04
• Solubility: DMSO : 50 mg/mL (ultrasonic)
• Smiles: CC(/C=C(S1)/C(N(CCCC(NC2=CC(O)=C(C(O)=O)C=C2)=O)C1=S)=O)=C\C3=CC=CC=C3
• Molecular Weight: 482.57
• References & Citations: [1]Heynen-Genel S, et al. Selective GPR35 Antagonists - Probes 1 & 2. National Center for Biotechnology Information (US); 2010-2010 Feb 28.|[2]Laura Jenkins, et al. Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J Pharmacol Exp Ther. 2012 Dec;343(3):683-95.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported