CD8a (Rabbit PAb), 0.2mg/mL

• Description :

  CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha) . A majority of thymocytes and a subpopulation of mature T cells and NK cell express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4 /CD8-. Anaplastic large cell lymphoma is usually CD4 and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

• Synonyms :

  CD8 antigen, alpha polypeptide (p32), T8/Leu-2 T-lymphocyte differentiation antigen, Ly3, LYT3, MAL, T-cell surface glycoprotein CD8 alpha chain

• UNSPSC :

  41116161

• UNSPSC Description :

  Primary and secondary antibodies for multiple methodology immunostaining detection application

• Gene Name :

  CD8A

• Gene ID :

  925

• NCBI Gene ID :

  85258

• UniProt :

  P01732

• Swiss Prot :

  P01732

• Host :

  Rabbit

• Species Reactivity :

  Human

• Reactivity :

  CD8A

• Immunogen :

  Human CD8 recombinant fragment corresponding to aa 200-250

• Target Antigen :

  CD8A

• Clonality :

  Polyclonal

• Clone :

  PAb

• Type :

  Primary

• Source :

  Animal

• Origin :

  Animal

• Field of Research :

  Immunology

• Positive Control :

  HuT78 or hPBL. Tonsil

• Stability :

  2 years

• Concentration :

  0.2 mg/mL

• Buffer :

  PBS, 0.05% BSA, 0.05% azide

• Molecular Weight :

  32 kDa

• Shipping Conditions :

  RT (ND)

• Storage Conditions :

  Stable at room temperature or 37°C (98°F) for 7 days.

• Shelf Life :

  Guaranteed for at least 24 months from date of receipt when stored as recommended

• Fragment :

  IgG

• Species :

  Oryctolagus cuniculus (domestic rabbit), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

• Classification :

  PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)

• CAS Number :

  9007-83-4

• Conjugate :

  Purified, with BSA