CD8 (RIV11), 0.2mg/mL

• Description :

  Recognizes a protein of 32 kDa, identified as CD8a (also known as CD8 chain, T cell co-receptor, Leu2, and T8) . CD8 molecule consists of two chains, termed and chain, which are expressed as a disulphide-linked heterodimer or as an homodimer. CD8 is expressed on T cell subset (cytotoxic/suppressor T cells), thymocytes and NK cells. The majority of CD8 T-cells expresses CD8 as heterodimer. Some subpopulation of CD8 T cells as well as NK cells may express homodimer. CD8 functions as a co-receptor in concert with TCR for binding the MHC class I/peptide complex. The HIV-2 envelope glycoprotein binds CD8 chain (but not chain) . The cytoplasmic domain of CD8 associates with p56lck tyrosine kinase. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

• CAS Number :

  9007-83-4

• Synonyms :

  CD8 antigen, alpha polypeptide (p32), T8/Leu-2 T-lymphocyte differentiation antigen, Ly3, LYT3, MAL, T-cell surface glycoprotein CD8 alpha chain

• UNSPSC :

  41116161

• UNSPSC Description :

  Primary and secondary antibodies for multiple methodology immunostaining detection application

• Gene Name :

  CD8A

• Gene ID :

  925

• NCBI Gene ID :

  85258

• UniProt :

  P01732

• Swiss Prot :

  P01732

• Host :

  Mouse

• Species Reactivity :

  Human

• Reactivity :

  CD8

• Immunogen :

  Human peripheral lymphocytes

• Target Antigen :

  CD8

• Clonality :

  Monoclonal

• Clone :

  RIV11

• Type :

  Primary

• Source :

  Animal

• Origin :

  Animal

• Applications :

  Flow, surface (verified) |IF (verified)

• Field of Research :

  Immunology

• Positive Control :

  HuT78 or hPBL. Tonsil

• Stability :

  2 years

• Concentration :

  0.2 mg/mL

• Buffer :

  PBS, 0.05% BSA, 0.05% azide

• Molecular Weight :

  32 kDa

• References & Citations :

  Note: References for this clone sold by other suppliers may be listed for expected applications. Knapp W. et. al. Leukocyte Typing IV, p342-343, Oxford University Press, 1989.

• Shipping Conditions :

  RT (ND)

• Storage Conditions :

  Stable at room temperature or 37°C (98°F) for 7 days.

• Shelf Life :

  Guaranteed for at least 24 months from date of receipt when stored as recommended

• Fragment :

  IgG1, kappa

• Species :

  Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

• Classification :

  PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)

• Conjugate :

  Purified, with BSA