Gynostemma Extract

• Description:

  Gynostemma Extract (Gypenoside IX) is a triterpenoid saponin. Gynostemma Extract can be isolated from Panax notoginseng. Gynostemma Extract reduces NFκB nuclear translocation and transcriptional activity by inhibiting the p38 MAPK/Akt/NFκB signaling pathway. Gynostemma Extract reduces the expression of cytokines (COX-2, IL-6) and the production of NO. Gynostemma Extract has anti-inflammatory activity. Gynostemma Extract can be used in the study of liver injury and neuroinflammation[1][2].

• Product Name Alternative:

  Ginsenoside C-Mx1; Gypenoside IX

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Akt; COX; Interleukin Related; NF-κB; NO Synthase; p38 MAPK

• Type:

  Natural Products

• Related Pathways:

  Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; PI3K/Akt/mTOR

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Metabolic Disease; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/Gynostemma-Extract.html

• Purity:

  99.92

• Solubility:

  DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O[C@H]1[C@H] (O) [C@@H] (CO) O[C@@H] (O[C@@H]2C (C) (C) [C@@] (CC[C@]3 (C) [C@]4 ([H]) C[C@@H] (O) [C@@]5 ([H]) [C@@]3 (C) CC[C@@H]5[C@] (O[C@@H]6O[C@H] (CO[C@@H]7OC[C@@H] (O) [C@H] (O) [C@H]7O) [C@@H] (O) [C@H] (O) [C@H]6O) (C) CC/C=C (C) \C) ([H]) [C@]4 (C) CC2) [C@@H]1O

• Molecular Formula:

  C47H80O17

• Molecular Weight:

  917.13

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Yoshikawa M, et al. Structures of new dammarane-type Triterpene Saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal Ginseng Saponins. J Nat Prod. 2003 Jul;66 (7) :922-7. |[2]Wang X, et al. Gypenoside IX Suppresses p38 MAPK/Akt/NFκB Signaling Pathway Activation and Inflammatory Responses in Astrocytes Stimulated by Proinflammatory Mediators. Inflammation. 2017 Dec;40 (6) :2137-2150.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  COX-2; IL-6

• CAS Number:

  80321-63-7