Human Recombinant B7-H4

• Description:

  Human Recombinant B7-H4_x000D_ Catalog number: B2017003_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 50 µg_x000D_ Molecular Weight or Concentration: 52.3 kDa_x000D_ Supplied as: Powder_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -80°C_x000D_ Keywords: B7 Homolog 4, B7h.5, B7S1, B7x, Immune Costimulatory Protein B7-H4, PRO1291, V-set Domain-containing T cell Activation Inhibitor 1, VCTN1_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Kinneer K, Wortmann P, Cooper ZA, Dickinson NJ, Masterson L, Cailleau T, Hutchinson I, Vijayakrishnan B, McFarlane M, Ball K, Davies M, Lewis A, Huang Y, Rosenbaum AI, Yuan J, Chesebrough J, Anderton J, Monks N, Novick S, Wang J, Dimasi N, Christie RJ, Sabol D, Tosto FA, Wallez Y, Leo E, Albertella MR, Staniszewska AD, Tice DA, Howard PW, Luheshi N, Sapra P. Design and Preclinical Evaluation of a Novel B7-H4-Directed Antibody-Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305 Clin Cancer Res. 2023 Mar 14;29(6):1086-1101._x000D_ 2: Dangaj D, Lanitis E, Zhao A, Joshi S, Cheng Y, Sandaltzopoulos R, Ra HJ, Danet-Desnoyers G, Powell DJ Jr, Scholler N. Novel recombinant human b7-h4 antibodies overcome tumoral immune escape to potentiate T-cell antitumor responses Cancer Res. 2013 Aug 1;73(15):4820-9._x000D_ 3: Mao YX, Chen YJ, Ge Y, Ma HB, Yu JF, Wu HY, Hu YM, Wang Q, Shi Q, Zhang XG. Recombinant human B7-H4 expressed in Escherichia coli inhibits T lymphocyte proliferation and IL-2 secretion in vitro Acta Pharmacol Sin. 2006 Jun;27(6):741-6._x000D_ 4: Wang X, Wang T, Xu M, Xiao L, Luo Y, Huang W, Zhang Y, Geng W. B7-H4 overexpression impairs the immune response of T cells in human cervical carcinomas Hum Immunol. 2014 Dec;75(12):1203-9._x000D_ 5: Ji H, Guo J, Yang Y, Xu C, Mao W. Construction, expression and functional analysis of anti-B7-H4- scFv-CH3 recombinant antibody J Biosci. 2018 Sep;43(4):661-671._x000D_ 6: Cheng L, Jiang J, Gao R, Wei S, Nan F, Li S, Kong B. B7-H4 expression promotes tumorigenesis in ovarian cancer Int J Gynecol Cancer. 2009 Dec;19(9):1481-6._x000D_ 7: Hong B, Qian Y, Zhang H, Sang YW, Cheng LF, Wang Q, Gao S, Zheng M, Yao HP. Expression of B7-H4 and hepatitis B virus X in hepatitis B virus-related hepatocellular carcinoma World J Gastroenterol. 2016 May 14;22(18):4538-46._x000D_ 8: Ou D, Wang X, Metzger DL, Ao Z, Pozzilli P, James RF, Chen L, Warnock GL. Suppression of human T-cell responses to beta-cells by activation of B7-H4 pathway Cell Transplant. 2006;15(5):399-410._x000D_ 9: Yuan L, Ye J, Fan D. The B7-H4 gene induces immune escape partly via upregulating the PD-1/Stat3 pathway in non-small cell lung cancer Hum Immunol. 2020 May;81(5):254-261._x000D_ 10: Shao L, Xu C, Ji H, Mao W, Wang Y, Liu X, Zhu Y. [Construction of anti-B7-H4-scFv library and screening and identification of anti-B7-H4-scFv] Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016 Sep;32(9):1260-6._x000D_ _x000D_ Products Related to Human Recombinant B7-H4 can be found at Proteins

• Short Description:

  Catalog Number: B2017003 (50 µg)_x000D_ Human Recombinant B7-H4 is a high quality protein that belongs to the B7 family of immune checkpoint molecules. It is involved in regulating immune responses and is known to play a role in inhibiting T cell activation and proliferation. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3