Vinblastine (sulfate)

• UNSPSC Description:

  Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM.

• Target Antigen:

  Autophagy; Microtubule/Tubulin

• Type:

  Natural Products

• Related Pathways:

  Autophagy;Cell Cycle/DNA Damage;Cytoskeleton

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Vinblastine-sulfate.html

• Smiles:

  [H][C@@]12C[C@@](C3=C(OC)C=C(N([C@]4([H])[C@@]56[C@]7([H])[C@](C=CCN7CC6)(CC)[C@@H](OC(C)=O)[C@@]4(C(OC)=O)O)C)C5=C3)(C(OC)=O)C(NC8=C9C=CC=C8)=C9CC[N@](C2)C[C@](O)(CC)C1.OS(=O)(O)=O

• Molecular Weight:

  909.0526

• References & Citations:

  [1]McKay DB, et al. Nicotinic and nonnicotinic receptor-mediated actions of vinblastine. Proc Soc Exp Biol Med. 1993 Jul;203(3):372-6.|[2]Pandya P, et al. Molecular recognition pattern of cytotoxic alkaloid vinblastine with multiple targets. J Mol Graph Model. 2014 Nov;54:1-9.|[3]Calvi?o E, et al. JNK and NFκB dependence of apoptosis induced by vinblastine in human acute promyelocytic leukaemia cells. Cell Biochem Funct. 2015 Jun;33(4):211-9.|[4]Selimovic D, et al. Vinblastine-induced apoptosis of melanoma cells is mediated by Ras homologous A protein (Rho A) via mitochondrial and non-mitochondrial-dependent mechanisms. Apoptosis. 2013 Aug;18(8):980-97.|[5]Bánóczi Z, et al. Synthesis and in vitro antitumor effect of vinblastine derivative-oligoarginine conjugates. Bioconjug Chem. 2010 Nov 17;21(11):1948-55.Biochem Pharmacol. 2020 May;175:113865.|Cancer Immunol Res. 2023 May 3;11(5):583-599.|Cell Rep Methods. 2023 Oct 23;3(10):100599.|Cells. 2022, 11(19), 2942.|Int J Biol Macromol. 2022 Jun 16;S0141-8130(22)01308-3.|J Biol Chem. 2021, 100525.|Mol Cell Biochem. 2021 Feb;476(2):1233-1243.|Mol Pharm. 2022 Oct 21.|Mutat Res Genet Toxicol Environ Mutagen. 2016 Sep 15;808:27-37. |PLoS Pathog. 2021 Aug 9;17(8):e1009838.|Food Chem. 2023 Jun 22, 136707.|Int J Clin Exp Pathol. 2017;10(3):3033-3042.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  143-67-9