Metoclopramide

CAT: 0804-HY-17382-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-17382-01Size:100 mg
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Description
Metoclopramide is a potent antagonist of 5-HT3 and dopamine D2 receptor, with IC50s of 308 nM and 483 nM, respectively. Metoclopramide can be used for the research of nausea and vomiting, gastro-oesophageal reflux, and gastroparesis[1][2].
CAS Number
[364-62-5]
UNSPSC
12352005
Hazard Statement
H302
Target
5-HT Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/Metoclopramide.html
Purity
99.98
Solubility
DMSO : 110 mg/mL (ultrasonic)
Smiles
O=C(NCCN(CC)CC)C1=CC(Cl)=C(N)C=C1OC
Molecular Formula
C14H22ClN3O2
Molecular Weight
299.80
Precautions
H302
References & Citations
[1]Hirokawa Y, et, al. Synthesis and structure-activity relationships of 4-amino-5-chloro-N- (1,4-dialkylhexahydro-1,4-diazepin-6-yl) -2-methoxybenzamide derivatives, novel and potent serotonin 5-HT3 and dopamine D2 receptors dual antagonist. Chem Pharm Bull (Tokyo) . 2002 Jul;50 (7) :941-59.|[2]Rao AS, et, al. Review article: metoclopramide and tardive dyskinesia. Aliment Pharmacol Ther. 2010 Jan;31 (1) :11-9.|[3]Edwards CR, et, al. In vivo and in vitro studies on the effect of metoclopramide on aldosterone secretion. Clin Endocrinol (Oxf) . 1980 Jul;13 (1) :45-50.|[4]Bhosale KB, et, al. Dose-dependent response of central dopaminergic systems to metoclopramide in mice. Indian J Exp Biol. 1997 Jun;35 (6) :618-22.|[5]Gomes RCT, et, al. Effects of metoclopramide on the mouse anterior pituitary during the estrous cycle. Clinics (Sao Paulo) . 2011;66 (6) :1101-4.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
D2 Receptor; lactoferrin

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