Anti-Desmoglein-3 (Squamous Cell Marker)(DSG3/2840)
CAT:
37-BNUM2840-50
Size:
50 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Anti-Desmoglein-3 (Squamous Cell Marker)(DSG3/2840)
- Description: Recognizes a protein of 130 kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Synonyms: 130kDa pemphigus vulgaris antigen (PVA); Balding (Bal); Cadherin family member 6 (CDHF6); Desmoglein-3 (DSG3)
- CAS Number: 9007-83-4
- UNSPSC: 41116161
- UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
- Gene Name: DSG3
- Gene ID: 1830
- NCBI Gene ID: 1925
- UniProt: P32926
- Cellular Locus: Plasma membrane
- Host: Mouse
- Species Reactivity: Human
- Immunogen: Recombinant fragment (around aa 379-491) human DSG3 protein (exact sequence is proprietary)
- Target Antigen: Desmoglein-3
- Clonality: Monoclonal
- Isotype: IgG1 κ
- Clone: DSG3/2840
- Conjugation: Purified, BSA-free
- Disease: Tumor
- Source: Animal
- Applications: IHC, FFPE (verified)
- Validated Applications: IHC, FFPE
- Positive Control: A431 cells. Skin or Lung Squamous Cell Carcinoma (SCC).
- Concentration: 1 mg/mL
- Buffer: PBS, no BSA, no azide
- Molecular Weight: 130 kDa
- Shipping Conditions: Room temperature
- Storage Conditions: -35°C to -5°C ; Stable at room temperature or 37°C (98°F) for 7 days.
- Shelf Life: 2 years