Anti-Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) (TYRP1/2340R)

• Description:

  This antibody reacts with a 75 kDa melanocyte-specific gene product, identified as Tyrosinase-Related Protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

• Synonyms:

  5; 6 dihydroxyindole 2 carboxylic acid oxidase; 6-dihydroxyindole-2-carboxylic acid oxidase; Associated with iris pigmentation; CAS2; Catalase B (CATB); DHICA oxidase; Glycoprotein75 (GP75); Melanoma antigen gp75; Tyrosinase-related protein 1 (TYRP1); TYRRP

• UNSPSC:

  41116161

• UNSPSC Description:

  Primary and secondary antibodies for multiple methodology immunostaining detection application

• Gene Name:

  TYRP1

• Gene ID:

  7306

• NCBI Gene ID:

  270279

• UniProt:

  P17643

• Cellular Locus:

  Vesicular

• Host:

  Rabbit

• Species Reactivity:

  Human

• Immunogen:

  Recombinant fragment of human TYRP1 protein (around aa 257-377) (exact sequence is proprietary)

• Target Antigen:

  Tyrosinase Related Protein-1

• Clonality:

  Recombinant Monoclonal

• Isotype:

  IgG

• Clone:

  TYRP1/2340R

• Conjugation:

  Purified, BSA-free

• Disease:

  Tumor

• Source:

  Animal

• Applications:

  IHC, FFPE (verified)

• Validated Applications:

  IHC, FFPE

• Field of Research:

  Cancer

• Positive Control:

  SK-MEL-23, SK-MEL-19, SK-MEL-30 cells. Human Skin or Melanoma.

• Concentration:

  1 mg/mL

• Buffer:

  PBS, no BSA, no azide

• Molecular Weight:

  75 kDa

• Additionnal Information:

  Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|ELISA: 2-4 ug/m for coating order Ab without BSA|Immunohistology (formalin): 1-2 ug/mL for 30 minutes at RT|Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at RT for 20 minutes|Optimal dilution for a specific application should be determined by user

• Shipping Conditions:

  Room temperature

• Storage Conditions:

  -35°C to -5°C ; Stable at room temperature or 37°C (98°F) for 7 days.

• Shelf Life:

  2 years

• CAS Number:

  9007-83-4