EGFR-IN-95

• UNSPSC Description:

  EGFR-IN-95 (compound 5j) is an 2,4-diaminonicotinamide derivative. EGFR-IN-95 has potent inhibitory activity against EGFR del19/T790M/C797S and L858R/T790M/C797S[1].

• Target Antigen:

  EGFR

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/egfr-in-95.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=C(C=C(N=C1)NC2=CC=NC(C3=CN(N=C3)S(=O)(C4CC4)=O)=N2)N[C@H](CC)C)NCCC(F)F

• Molecular Weight:

  534.58

• References & Citations:

  [1]Hideaki Kageji, et al. Synthesis, activity, and their relationships of 2,4-diaminonicotinamide derivatives as EGFR inhibitors targeting C797S mutation. Bioorg Med Chem Lett. 2023.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3027135-04-9