Asiatic acid

CAT: 0804-HY-N0194-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0194-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Asiatic acid, a pentacyclic triterpene found in Centella asiatica (Centella asiatica), has anticancer activity. Asiatic acid induces apoptosis in melanoma cells and has barrier protective effects on human aortic endothelial cells (HAEC) . Asiatic acid also has anti-inflammatory activity and inhibits tumor necrosis factor (TNF) -α-induced endothelial barrier dysfunction. Asiatic acid also inhibits NLRP3 inflammasome activation and NF-κB pathway, effectively inhibits inflammation in rats, and has neuroprotective effects in rat spinal cord injury (SCI) model[1][2][3][4][5].
CAS Number
[464-92-6]
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Parasite
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/asiatic-acid.html
Concentration
10mM
Purity
99.49
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
C[C@@]1(CO)[C@@H](O)[C@H](O)C[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@](C(O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H]
Molecular Formula
C30H48O5
Molecular Weight
488.70
Precautions
H302, H315, H319, H335
References & Citations
[1]Park BC, et al. Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells. Cancer Lett. 2005 Jan 31;218 (1) :81-90.|[2]Huang SS, et al. Antinociceptive activities and the mechanisms of anti-inflammation of asiatic Acid in mice. Evid Based Complement Alternat Med. 2011;2011:895857.|[3]Fong LY, et al. Asiatic acid stabilizes cytoskeletal proteins and prevents TNF-α-induced disorganization of cell-cell junctions in human aortic endothelial cells. Vascul Pharmacol. 2019 Jun;117:15-26.|[4]Jiang W, et al. Neuroprotective effect of asiatic acid against spinal cord injury in rats. Life Sci. 2016 Jul 15;157:45-51.|[5]Kong D, et al. Protective effects of Asiatic acid against pelvic inflammatory disease in rats. Exp Ther Med. 2019 Jun;17 (6) :4687-4692.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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