Pancreas/duodenum homeobox protein 1 Antibody / PDX1

• Description:

  Pancreatic duodenal homeobox-1 protein (PDX-1), also designated Insulin promoter factor (IPF1), Insulin upstream factor 1 (IUF1), somatostatin transactivating factor-1 (STF-1) and glucose-sensitive factor (GSF), is a 282 amino acid homeodomain-containing transcription factor present in pancreatic cells. PDX-1 binds to the sequence C (C/T) and can heterodimerize with PBX. PDX-1 is phosphorylated by the SAPK2 pathway under high glucose concentrations. Mutations in the PDX-1 gene can cause maturity-onset diabetes of the young and pancreatic agenesis. The gene which encodes PDX-1 maps to human chromosome 13q12.2.

• Specifications:

  Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-2 µg/mL

• UniProt:

  P52945

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Recombinant full-length human PDX1 protein was used as the immunogen for the Pancreas/duodenum homeobox protein 1 antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG2c

• Clone:

  PCRP-PDX1-2C11

• Applications:

  FACS, IF

• Purity:

  Protein A/G affinity

• Format:

  Purified

• Buffer:

  1 mg/ml in 1X PBS; BSA free, sodium azide free

• Reconstitution:

  Aliquot the Pancreas/duodenum homeobox protein 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations:

  This Pancreas/duodenum homeobox protein 1 antibody is available for research use only.

• Storage Conditions:

  Aliquot the Pancreas/duodenum homeobox protein 1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation:

  1 mg/mL in 1X PBS; BSA free, sodium azide free

• Applications Notes:

  Optimal dilution of the Pancreas/duodenum homeobox protein 1 antibody should be determined by the researcher.

• CAS Number:

  9007-83-4

• Location:

  Nucleus

• Image Legend:

  Immunofluorescent staining of PFA-fixed human HeLa cells using Pancreas/duodenum homeobox protein 1 antibody (green, clone PCRP-PDX1-2C11) and phalloidin (red) .