Beta Catenin Recombinant Antibody

Beta Catenin Recombinant Antibody

• Description: Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.
• CAS Number: 9000-83-3
• UniProt: P35222
• Host: Mouse
• Immunogen: Recombinant full-length human Beta-Catenin/CTNNB1 protein was used as the immunogen for the recombinant Catenin Beta antibody.
• Clonality: Monoclonal
• Isotype: IgG1 κ
• Type: Recombinant
• Applications: IHC-P
• Format: Purified
• Buffer: 1 mg/ml in 1X PBS; BSA free, sodium azide free
• Reconstitution: Aliquot the recombinant Catenin Beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
• Limitations: This recombinant Catenin Beta antibody is available for research use only.