AMG 900

AMG 900

• CAS Number: 945595-80-2
• UNSPSC Description: AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor with IC50 of 5 nM, 4 nM and 1 nM for Aurora A, B and C, respectively.
• Target Antigen: Aurora Kinase
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/amg-900.html
• Purity: 99.29
• Solubility: DMSO : ≥ 50 mg/mL
• Smiles: CC1=CSC(C2=NN=C(C3=C2C=CC=C3)NC4=CC=C(C=C4)OC5=C(C=CC=N5)C6=CC=NC(N)=N6)=C1
• Molecular Weight: 503.58
• References & Citations: [1]Payton M, et al. Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines. Cancer Res, 2010, 70(23), 9846-9854.|[2]Juan G, et al. AMG 900, a potent inhibitor of aurora kinases causes pharmacodynamic changes in p-Histone H3 immunoreactivity in human tumor xenografts and proliferating mouse tissues. J Transl Med. 2014 Nov 4;12:307.|[3]Huang L, et al. In vitro and in vivo pharmacokinetic characterizations of AMG 900, an orally bioavailable small molecule inhibitor of aurora kinases. Xenobiotica. 2011 May;41(5):400-8.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Phase 1