C-Myb Antibody

• Description:

  The highly leukemogenic avian retrovirus E26 contains two oncogenes, v-Myb and v-Ets, which are expressed together as a fusion protein. The cellular homolog of v-Myb, designated c-Myb, encodes a transcription factor. Deletion or disruption of a negative regulatory domain mapping within the carboxy-terminal domain of c-Myb results in enhanced transactivating capacity and in parallel, leads to activation of its ability to transform hemopoietic cells. c-Myb is expressed preferentially, but not exclusively, in immature hemopoietic cells and its expression decreases as cells differentiate.

• Specifications:

  ELISA: 2-4 µg/mL (order BSA/azide-free format)

• UniProt:

  P01104

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Amino acids 119-135 (RRKVEQEGYPQESSKAG) from the human protein were used as the immunogen for this c-Myb antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG1 k

• Clone:

  MYB286

• Applications:

  ELISA

• Purity:

  Protein G affinity chromatography

• Format:

  Purified

• Buffer:

  1 mg/ml in 1X PBS; BSA free, sodium azide free

• Reconstitution:

  Store the c-Myb antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

• Limitations:

  This c-Myb antibody is available for research use only.

• Storage Conditions:

  Store the c-Myb antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

• Formulation:

  1 mg/mL in 1X PBS; BSA free, sodium azide free

• Applications Notes:

  The optimal dilution of the c-Myb antibody for each application should be determined by the researcher.

• CAS Number:

  9007-83-4

• Location:

  Nuclear