Neurofilament Antibody (-Light) / NF-L / NEFL

Neurofilament Antibody (-Light) / NF-L / NEFL

• Description: This mAb reacts with a 68kDa protein, identified as light sub-unit of neurofilaments (NF-L). Neurofilaments make up the main structural elements of axons and dendrites and are found in neurons, peripheral nerves, and sympathetic ganglion cells. Neurofilaments consist of three major subunits with molecular weights of 68kDa (NF-L), 160kDa (NF-M) and 200kDa (NF-H). Anti-neurofilament stains a number of neural, neuroendocrine, and endocrine tumors. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas, and neuroblastomas stain positively for anti-neurofilament. Neurofilaments are also present in paragangliomas as well as adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and cell carcinomas of the lung also express neurofilament.
• CAS Number: 9007-83-4
• UniProt: P07196
• Host: Mouse
• Immunogen: Crude neurofilament preparation from porcine spinal cord was used as the immunogen for the Neurofilament antibody.
• Clonality: Monoclonal
• Isotype: IgG1 κ
• Applications: IF, FACS, IHC-P
• Format: Purified
• Buffer: 1 mg/ml in 1X PBS; BSA free, sodium azide free
• Reconstitution: Store the Neurofilament antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
• Limitations: This Neurofilament antibody is available for research use only.