Androgen Receptor Antibody

Androgen Receptor Antibody

• Description: Recognizes a protein of 100kDa, which is identified as androgen receptor (AR). It reacts with full length, and the newly described A form of the receptor. It does not cross react with estrogen, progesterone, or glucocorticoid receptors. The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed, as a marker of hormone-responsiveness and thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin. This mAb is superb for staining of formalin/paraffin tissues.
• CAS Number: 9007-83-4
• UniProt: P10275
• Host: Mouse
• Immunogen: Amino acids 302-318 (STEDTAEYSPFKGGYTK) from human AR were used as the immunogen for the anti-Androgen Receptor antibody.
• Clonality: Monoclonal
• Isotype: IgG1 κ
• Applications: IHC-P
• Format: Purified
• Buffer: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
• Reconstitution: Store the anti-Androgen Receptor antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
• Limitations: This anti-Androgen Receptor antibody is available for research use only.