PD-L1 Antibody / B7-H1 / CD274

PD-L1 Antibody / B7-H1 / CD274

• Description: Programmed death-ligand 1 (PD-L1), also known as CD274 or B7-H1, is a protein that in humans is encoded by the CD274 gene. It is mapped to 9p24.1. PD-L1 is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. It has been concluded that upregulation of PD-L1 on tumor MDCs downregulates T-cell immunity and that PD-L1 blockade may represent an approach for cancer immunotherapy. Additionally, PD-L1 can provide positive costimulatory signals for innate and adaptive immunity and for protection against intracellular bacterial infection. What’s more, it has been found that PD1/PDL1 pathway may be a good target for restoring antitumor immunity in ovarian cancer.
• CAS Number: 9007-83-4
• UniProt: Q9EP73
• Host: Rabbit
• Immunogen: Amino acids F19-T238 from the mouse protein were used as the immunogen for the PD-L1 antibody.
• Clonality: Polyclonal
• Isotype: IgG
• Applications: WB, ELISA (protein)
• Format: Antigen affinity purified
• Buffer: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Reconstitution: Prior to reconstitution, store at 4oC. After reconstitution, the PD-L1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
• Limitations: This PD-L1 antibody is available for research use only.