IL-23 Antibody (p19/alpha subunit)

• Description:

  Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

• Specifications:

  Western blot: 1:2000

• UniProt:

  Q9NPF7

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  Amino acids 33-67 from the human protein were used as the immunogen for this IL-23 antibody.

• Clonality:

  Polyclonal

• Isotype:

  Ig

• Applications:

  WB

• Purity:

  Antigen affinity

• Format:

  Antigen affinity purified

• Limitations:

  This IL-23 antibody is available for research use only.

• Storage Conditions:

  Aliquot the IL-23 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Applications Notes:

  The stated application concentrations are suggested starting points. Titration of the IL-23 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

• Prediction Reactivity:

  Human

• CAS Number:

  9007-83-4

• Image Legend:

  Western blot testing of IL-23 antibody at 1:2000 dilution + mouse pancreas lysate. Predicted molecular weight ~21 kDa, observed molecular weight ~19 kDa.