Fibroblast Growth Factor Receptor 3 Antibody (FGFR3)

Fibroblast Growth Factor Receptor 3 Antibody (FGFR3)

• Description: FGFR3 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.
• UniProt: P22607
• Host: Rabbit
• Immunogen: A portion of amino acids 776-806 from the human protein was used as the immunogen for this FGFR3 antibody.
• Clonality: Polyclonal
• Isotype: Ig
• Applications: WB, IHC, ELISA
• Format: Purified
• Buffer: In 1X PBS, pH 7.4, with 0.09% sodium azide
• Reconstitution: Aliquot the FGFR3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
• Limitations: This FGFR3 antibody is available for research use only.