RGD peptide (GRGDNP)

• UNSPSC Description:

  RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation[1][2][3].

• Target Antigen:

  Apoptosis; Caspase; Integrin

• Type:

  Peptides

• Related Pathways:

  Apoptosis;Cytoskeleton

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/rgd-peptide.html

• Purity:

  99.63

• Solubility:

  DMSO : 3.12 mg/mL (ultrasonic)|H2O : ≥ 100 mg/mL

• Smiles:

  O=C(O)[C@H]1N(C([C@H](CC(N)=O)NC([C@H](CC(O)=O)NC(CNC([C@H](CCCNC(N)=N)NC(CN)=O)=O)=O)=O)=O)CCC1

• Molecular Weight:

  614.61

• References & Citations:

  [1]C D Buckley, et al. RGD peptides induce apoptosis by direct caspase-3 activation. Nature. 1999 Feb 11;397(6719):534-9.|[2]Wei Xia, et al. Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors. Nat Commun. 2021 Oct 15;12(1):6043.|[3]Akitoshi Sasamoto, et al. Mechanotransduction by integrin is essential for IL-6 secretion from endothelial cells in response to uniaxial continuous stretch. Am J Physiol Cell Physiol. 2005 May;288(5):C1012-22.Adv Mater. 2024 Jul 18:e2406140.|Biofabrication. 2021 Apr 9.|Biomacromolecules. 2023 Mar 21.|bioRxiv. 2024 October 06.|Cell Death Dis. 2022 Jul 1;13(7):577.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  114681-65-1