Amantadine (hydrochloride)
CAT:
804-HY-B0402A-03
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Amantadine (hydrochloride)
- CAS Number: 665-66-7
- UNSPSC Description: Amantadine (1-Adamantanamine) hydrochloride is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine hydrochloride inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine hydrochloride also has anti-orthopoxvirus and anticancer activity. Amantadine hydrochloride can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[1][2][3][4][5][6].
- Target Antigen: Apoptosis; Bcl-2 Family; CDK; Influenza Virus; Orthopoxvirus; SARS-CoV
- Type: Reference compound
- Related Pathways: Anti-infection;Apoptosis;Cell Cycle/DNA Damage
- Applications: COVID-19-anti-virus
- Field of Research: Cancer; Infection; Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/Amantadine-hydrochloride.html
- Purity: 98.0
- Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : ≥ 50 mg/mL
- Smiles: NC1(C2)C[C@@H]3C[C@@H](C[C@H]2C3)C1.Cl
- Molecular Weight: 187.71
- References & Citations: [1]Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200.|[2]Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78(14):1096-1099.|[3]Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52. |[4]Fink K, et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 Mar 24;13(4):539. |[5]Zhang J, et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 Oct;121(4):773-85. |[6]Lan Z, et al. Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro. Int J Mol Med. 2015;36(3):904-910.Chem Phys Lipids. 2024 May 11:262:105397.|Int J Nanomedicine. 2019 Nov 27;14:9217-9234.|Signal Transduct Target Ther. 2021 Mar 27;6(1):134.|SSRN. 2024 Aug 7.
- Shipping Conditions: Room Temperature
- Storage Conditions: Store at room temperature, keep dry and cool
- Clinical Information: Launched