OPRS1 Antibody (N-term) [APR05067G]

• Background:

  Tissue Location: Widely expressed with higher expression in liver, colon, prostate, placenta, small intestine, heart and pancreas Expressed in the retina by retinal pigment epithelial cells. Expressed in alpha-motor neurons (PubMed:23314020) .

• Synonyms:

  Sigma non-opioid intracellular receptor 1, Aging-associated gene 8 protein, SR31747-binding protein, SR-BP, Sigma 1-type opioid receptor, SIG-1R, Sigma1-receptor, Sigma1R, hSigmaR1, SIGMAR1, OPRS1, SRBP

• Gene Name:

  SIGMAR1

• Gene ID:

  10280

• UniProt:

  Q99720

• Chromosomal Location:

  Nucleus inner membrane. Nucleus outer membrane. Nucleus envelope. Cytoplasmic vesicle. Endoplasmic reticulum membrane. Membrane; Single-pass membrane protein. Lipid droplet {ECO:0000250|UniProtKB:O55242}. Cell junction. Cell membrane. Cell projection, growth cone. Cell junction, synapse, postsynaptic density membrane. Note=During interphase, detected at the inner and outer nuclear membrane and the endoplasmic reticulum Detected on cytoplasmic vesicles during mitosis (PubMed:10406945) Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Accumulation at the endoplasmic reticulum is prominent in alpha-motor neurons of patients with amyotrophic lateral sclerosis (PubMed:23314020) . Enriched at cell-cell communication regions, growth cone and postsynaptic structures Localization is modulated by ligand-binding. In motor neurons it is enriched at cholinergic postsynaptic densities (By similarity) {ECO:0000250|UniProtKB:O55242, ECO:0000269|PubMed:10406945, ECO:0000269|PubMed:23314020}

• Applications:

  WB, FC

• Dilution:

  WB--1:1000 FC--1:10~50

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

• Function:

  164728039341151

• Molecular Weight:

  25128

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality OPRS1 Antibody (N-term) [APR05067G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=10280

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q99720