Myosin 1C (MYO1C) Antibody (C-term) [APR17517G]

• Synonyms:

  Unconventional myosin-Ic, Myosin I beta, MMI-beta, MMIb, MYO1C

• Gene Name:

  MYO1C

• Gene ID:

  4641

• UniProt:

  O00159

• Chromosomal Location:

  [Isoform 1]: Cytoplasm. Nucleus Note=Colocalizes with RNA polymerase II. Absent from nucleoli and does not colocalize with RNA polymerase I. Translocates to nuclear speckles upon exposure to inhibitors of RNA polymerase II transcription [Isoform 3]: Nucleus, nucleoplasm. Nucleus, nucleolus. Nucleus, nuclear pore complex. Note=Colocalizes with RNA polymerase II in the nucleus. Colocalizes with RNA polymerase I in nucleoli (By similarity) . In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC) Accumulates strongly in DFC and GC during activation of transcription Colocalizes with transcription sites. Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6. Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles Colocalizes with RPS6 at the nuclear pore level.

• Applications:

  WB, IHC-P

• Dilution:

  WB--1:1000 IHC-P--1:100~500

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

• Function:

  Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes.

• Molecular Weight:

  121682

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Myosin 1C (MYO1C) Antibody (C-term) [APR17517G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=4641

• Uniprot URL:

  https://www.uniprot.org/uniprot/O00159