A-3 (hydrochloride)

A-3 (hydrochloride)

• CAS Number: 78957-85-4
• UNSPSC Description: A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (Ki=4.3 μM), casein kinase II (Ki=5.1 μM) and myosin light chain kinase (MLCK) (Ki=7.4 μM). A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 μM and 80 μM, respectively[1].
• Target Antigen: CaMK; Casein Kinase; PKA; PKC
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics;Neuronal Signaling;Stem Cell/Wnt;TGF-beta/Smad
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/a-3-hydrochloride.html
• Purity: 99.75
• Solubility: DMSO : 125 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
• Smiles: O=S(C1=C2C=CC=C(Cl)C2=CC=C1)(NCCN)=O.[H]Cl
• Molecular Weight: 321.22
• References & Citations: [1]Inagaki M, et al. Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors. Mol Pharmacol. 1986 Jun;29(6):577-81.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported