REG3A Regenerating Islet-Derived 3 Alpha Human Recombinant Protein

• Description:

  The Recombinant Human REG3A protein is produced with N-terminal fusion of His Tag. The REG3A His -Tagged Fusion Protein is an 18.4 kDa protein containing 149 amino acid residues of the Human REG3A and 16 additional amino acid residues- His Tag (underlined) . Applications: ELISA, Western blot.

• Synonyms:

  Regenerating islet-derived protein 3 alpha; Reg III-alpha; Pancreatitis-associated protein 1; REG3A; HIP; PAP; PAP1; REG3; INGAP; PAP-H; PBCGF; REG-III

• Gene Name:

  REG3A

• UniProt:

  Q06141

• Reactivity:

  Human

• Tissue Specificity:

  Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level) . Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis.

• Source:

  Escherichia coli

• Sequence:

  [object Object]

• Applications:

  ELISA, WB

• Purification:

  Greater than 95.0% as determined by SDS-PAGE.

• Form:

  Filtered White lyophilized (freeze-dried) powder.

• Reconstitution:

  Add 0.1M acetate buffer pH4 to prepare ~0.5mg/ml working stock solution. For higher pH, dilute with relevant buffer to 10μg/ml. The antigen has limited solubility in higher concentrations. Non-sterile product; filter before use in cell culture.

• Function:

  Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.

• Shipping Conditions:

  Available

• Storage Conditions:

  Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

• Other Gene Names:

  Regenerating islet-derived protein 3-alpha

• Subcellular Location:

  Secreted. Found in the apical region of pancreatic acinar cells.