Human BACE1 (recombinant)

Human BACE1 (recombinant)_x000D_ Catalog number: B2016790_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 50 µg_x000D_ Molecular Weight or Concentration: 48.4 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -80°C_x000D_ Keywords: β-site Amyloid Precursor Protein Cleaving Enzyme 1, ASP-2, BACE, Memapsin 2, Membrane-bound Aspartic Protease_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Kariolis MS, Wells RC, Getz JA, Kwan W, Mahon CS, Tong R, Kim DJ, Srivastava A, Bedard C, Henne KR, Giese T, Assimon VA, Chen X, Zhang Y, Solanoy H, Jenkins K, Sanchez PE, Kane L, Miyamoto T, Chew KS, Pizzo ME, Liang N, Calvert MEK, DeVos SL, Baskaran S, Hall S, Sweeney ZK, Thorne RG, Watts RJ, Dennis MS, Silverman AP, Zuchero YJY. Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys Sci Transl Med. 2020 May 27;12(545):eaay1359._x000D_ 2: Yang HC, Chai X, Mosior M, Kohn W, Boggs LN, Erickson JA, McClure DB, Yeh WK, Zhang L, Gonzalez-DeWhitt P, Mayer JP, Martin JA, Hu J, Chen SH, Bueno AB, Little SP, McCarthy JR, May PC. Biochemical and kinetic characterization of BACE1: investigation into the putative species-specificity for beta- and beta'-cleavage sites by human and murine BACE1 J Neurochem. 2004 Dec;91(6):1249-59._x000D_ 3: Vilella A, Bodria M, Papotti B, Zanotti I, Zimetti F, Remaggi G, Elviri L, Potì F, Ferri N, Lupo MG, Panighel G, Daini E, Vandini E, Zoli M, Giuliani D, Bernini F. PCSK9 ablation attenuates Aβ pathology, neuroinflammation and cognitive dysfunctions in 5XFAD mice Brain Behav Immun. 2024 Jan;115:517-534._x000D_ 4: Pereira PA, Tomás JF, Queiroz JA, Figueiras AR, Sousa F. Recombinant pre-miR-29b for Alzheimer´s disease therapeutics Sci Rep. 2016 Jan 28;6:19946._x000D_ 5: Greco S, Zaccagnini G, Fuschi P, Voellenkle C, Carrara M, Sadeghi I, Bearzi C, Maimone B, Castelvecchio S, Stellos K, Gaetano C, Menicanti L, Martelli F. Increased BACE1-AS long noncoding RNA and β-amyloid levels in heart failure Cardiovasc Res. 2017 Apr 1;113(5):453-463._x000D_ 6: Lei X, Lei L, Zhang Z, Zhang Z, Cheng Y. Downregulated miR-29c correlates with increased BACE1 expression in sporadic Alzheimer's disease Int J Clin Exp Pathol. 2015 Feb 1;8(2):1565-74. eCollection 2015._x000D_ 7: Zhao L, Zhao Y, Tang FL, Xiong L, Su C, Mei L, Zhu XJ, Xiong WC. pHluorin-BACE1-mCherry Acts as a Reporter for the Intracellular Distribution of Active BACE1 In Vitro and In Vivo Cells. 2019 May 17;8(5):474._x000D_ 8: Otani T, Hattori Y, Akaji K, Kobayashi K. Macrocyclic BACE1 inhibitors with hydrophobic cross-linked structures: Optimization of ring size and ring structure Bioorg Med Chem. 2021 Dec 15;52:116517._x000D_ 9: Jabłkowski M, Szemraj M, Oszajca K, Janiszewska G, Bartkowiak J, Szemraj J. New type of BACE1 siRNA delivery to cells Med Sci Monit. 2014 Dec 10;20:2598-606._x000D_ 10: De Simone A, Mancini F, Cosconati S, Marinelli L, La Pietra V, Novellino E, Andrisano V. Human recombinant beta-secretase immobilized enzyme reactor for fast hits' selection and characterization from a virtual screening library J Pharm Biomed Anal. 2013 Jan 25;73:131-4. _x000D_ _x000D_ Products Related to Human BACE1 (recombinant) can be found at Proteins

9000-83-3

Catalog Number: B2016790 (50 µg)

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